Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism.
Luis Didier González-GarcíaMacario Martínez-CastilloTania Allin Vargas-PavíaJosé Manuel Ulloa-AguilarHaruki Arévalo-RomeroGuadalupe Léon-ReyesAddy Cecilia Helguera-RepettoJulio García-CorderoMoisés León-JuárezPublished in: Archives of virology (2021)
Respiratory syncytial virus (RSV) is most commonly associated with upper respiratory tract infections during childhood. The lipid composition of cells and lipogenic enzymes play an important role in RSV infection. There are controversial data about whether lipid biosynthesis regulators such as AMP-activated protein kinase (AMPK) are deregulated by RSV. Hence, we examined whether the activation state of AMPK is altered in RSV-infected HEp-2 cells. Our data show that RSV infection inhibits AMPK activity, favoring the activation of downstream lipogenic effectors and cellular lipid anabolism in HEp-2 cells.