Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells.

Wararat KittikulsuthPeter A FriedmanAlfred van HoekYang GaoDonald E Kohan

Published in: BMC nephrology (2017)

Taken together, these findings indicate that AC6 and AC9 mediate calcitonin- and PTH-stimulated cAMP accumulation in DCT cells, while activation of AC7 may paradoxically reduce the stimulatory effects of PTH and calcitonin on cultured DCT cAMP levels.

Keyphrases

induced apoptosis
cell cycle arrest
protein kinase
endoplasmic reticulum stress
endothelial cells
signaling pathway
oxidative stress
cell proliferation