Efficacy of immunotherapy in lung cancer with co-occurring mutations in NOTCH and homologous repair genes.

Marco MazzottaMarco FilettiMario OcchipintiDaniele MarinelliStefano ScaleraIrene TerrenatoFrancesca SperatiMatteo PalloccaFrancesco RizzoAlain GelibterAndrea BotticelliGiorgia ScafettaArianna Di NapoliEriseld KrasniqiLaura PizzutiMaddalena BarbaSilvia CarpanoPatrizia ViciMaurizio FanciulliFrancesca De NicolaLudovica CiuffredaFrauke GoemanRuggero De MariaAndrea VecchioneRaffaele GiustiGennaro CilibertoPaolo MarchettiMarcello Maugeri-Saccà

Published in: Journal for immunotherapy of cancer (2021)

Co-occurring mutations in the NOTCH and HR pathways are associated with increased efficacy of immunotherapy in advanced NSCLC. This genomic predictor deserves further investigation to fully assess its potential in informing therapeutic decisions.

Keyphrases

small cell lung cancer
cell proliferation
genome wide
copy number
gene expression
dna methylation