Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice.

Wei PanJinxiu ZhaoJiacheng WuDaxiang XuXianran MengPengfei JiangHongli ShiXing GeXiaoying YangMinmin HuPeng ZhangRenxian TangNathan NagaratnamKuiyang ZhengXu-Feng Huang Yinghua Yu

Published in: Microbiome (2023)

The present study provides the first evidence that DI improves cognition and brain function with significant beneficial effects via the gut-brain axis, suggesting that DI may serve as a novel drug for treating obesity-associated neurodegenerative diseases. Video Abstract.

Keyphrases

high fat diet
white matter
insulin resistance
resting state
cognitive impairment
high fat diet induced
functional connectivity
adipose tissue
metabolic syndrome
type diabetes
cerebral ischemia
multiple sclerosis
biofilm formation
emergency department
mild cognitive impairment
physical activity