Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation.
Antonio SorrentinoAyse Nur MenevseTillmann MichelsValentina VolpinFranziska Christine DurstJulian SaxMaria XydiaAbir HusseinSlava StamovaSteffen SpoerlNicole HeuschneiderJasmin MuehlbauerKatharina Marlene JeltschAnchana RathinasamyMelanie Werner-KleinMarco BreinigDamian MikietynChristian KohlerIsabel PoschkeSabrina PurrOlivia ReidellCatarina Martins FreireRienk OffringaClaudia GebhardRainer SpangMichael RehliMichael BoutrosChristian SchmidlNisit KhandelwalPhilipp BeckhovePublished in: Journal for immunotherapy of cancer (2022)
Our data reveal an abundant molecular mechanism that protects tumor cells from cytotoxic TC attack and demonstrate that pharmacological inhibition of this pathway is feasible.