Evolution of Nrf2 Gene Expression in HIT-T15 β-Cells During Chronic Oxidative Stress and Glucose Toxicity.

Tsehay AbebeLindsey BogachusAdithya Krishna VegarajuR Paul Robertson

Published in: Journal of the Endocrine Society (2022)

These complex events support the concept that Nrf2 gene expression plays an important regulatory role in defending beta cells during prolonged exposure to oxidative stress.

Keyphrases

oxidative stress
gene expression
induced apoptosis
dna methylation
diabetic rats
ischemia reperfusion injury
dna damage
cell cycle arrest
transcription factor
signaling pathway
heat shock
type diabetes
insulin resistance
skeletal muscle