Increased spontaneous CCL2 (MCP-1) and CCL5 (RANTES) secretion in vitro in LADA compared to type 1 diabetes and type 2 diabetes: Action LADA 14.

Mark OomsAlexander StromKlaus StrassburgerBarbara MenartRichard D LeslieNanette C Schloot

Published in: Diabetes/metabolism research and reviews (2021)

Chemokine secretion is altered between different diabetes types. Increased spontaneous secretion of CCL2 and CCL5 and decreased secretion of CCL2, upon stimulation with PI and pIA2, in LADA compared to T1D and T2D could reflect altered immune responsiveness in LADA patients in association with their slower clinical progression compared to insulin dependence.

Keyphrases

type diabetes
liver fibrosis
liver injury
glycemic control
drug induced
cardiovascular disease
end stage renal disease
newly diagnosed
ejection fraction
peritoneal dialysis