Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study.
Adem Y DawedKaixin ZhouNienke van LeeuwenAnubha MahajanNeil RobertsonRobert KoivulaPetra J M EldersSimone P RauhAngus G JonesReinhard W HollJulia C StinglPaul W FranksMark I McCarthyLeen M 't HartEwan R Pearsonnull nullPublished in: Diabetes care (2019)
These results suggest that intestinal metformin transporters and concomitant medications play an important role in the gastrointestinal adverse effects of metformin.