Identification of MRAP protein family as broad-spectrum GPCR modulators.
Meng WangXiaozhu WangBopei JiangYue ZhaiJihong ZhengLiu YangXiaolu TaiYunpeng LiShaliu FuJing XuXiaowei LeiZhe KuangCong ZhangXuanxuan BaiMingyu LiTao ZanShen QuQingfeng LiChao ZhangPublished in: Clinical and translational medicine (2022)
Collectively, our study has comprehensively elucidated the complex GPCR networks in two major endocrine organs and redefined the MRAP protein family as broad-spectrum GPCR modulators. MRAP proteins not only serve as a vital endocrine pivot on the regulation of global GPCR activities in vivo that could explain the composite physiological phenotypes of the MRAP2 null murine model but also provide us with new insights of the phenotyping investigation of GPCR-MRAP functional complexes.