A new transcript in the TCRB locus unveils the human ortholog of the mouse pre-Dß1 promoter.

Bernard LethéSylvia SnauwaertOrian BricardDavid SchröderTiphanie GomardGérald HamesCatherine MullerChristophe LurquinEmilie GauthyAhmed EssaghirBart VandekerckhovePierre G Coulie

Published in: Immunity, inflammation and disease (2017)

The X1 promoter appears to be the ortholog of the mouse pre-Dß1 promoter (PDß1). Like PDß1, its activation is regulated by Eß in T cells and might facilitate the TCRB rearrangement process by contributing to the accessibility of the Dß1 locus.

Keyphrases

dna methylation
transcription factor
gene expression
endothelial cells
genome wide association study
induced pluripotent stem cells
rna seq