First-line palliative systemic therapy alternated with oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy for unresectable colorectal peritoneal metastases: A single-arm phase II trial (CRC-PIPAC-II).
Paulien RauwerdinkVincent C J van de VlasakkerEmma C E WassenaarKoen P RoversMaartje LosKarin H HerbschlebGeert-Jan M CreemersAnnemarie M J ThijsMihaela G RaicuClément J R HuysentruytErik J R J van der HoevenJoost NederendRifka Y M PeetersMaarten J DeenenSjoerd G EliasRemond J A FijnemanAlexander ConstantinidesOnno KranenburgPim W A BurgerSimon W NienhuijsRené J WiezerRobin J LurvinkIgnace H J T de HinghDjamila BoermaPublished in: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (2024)
Combining palliative systemic therapy with oxaliplatin-based ePIPAC in patients with unresectable CPM was feasible and showed an acceptable safety profile. Treatment-induced response and survival are promising, yet further research is required to determine the additional value of ePIPAC to systemic therapy.