Natural course of scoliosis and lifetime risk of scoliosis surgery in spinal muscular atrophy.
Camiel A WijngaardeRob C BrinkFloor A S de KortMarloes StamLouise A M OttoFay-Lynn AsselmanBart BartelsRuben P A van EijkJoyce SombroekInge CuppenMarjolein VerhoefLeonard H van den BergRenske I WadmanRené M CasteleinLudo W van der PolPublished in: Neurology (2019)
The lifetime probability of scoliosis surgery is high in SMA types 1c and 2 and depends on age at loss of ambulation in type 3. Motor milestones such as standing that are not part of the standard classification system are of additional predictive value. Our data may act as a reference to assess long-term effects of new SMA-specific therapies.