Effect of NK-5962 on Gene Expression Profiling of Retina in a Rat Model of Retinitis Pigmentosa.
Shihui LiuMary MiyajiOsamu HosoyaToshihiko MatsuoPublished in: International journal of molecular sciences (2021)
signaling pathways. Overall, our RNA-seq and bioinformatics analyses provide insights in the transcriptome responses in the dystrophic RCS rat retinas that were induced by NK-5962 intravitreal injection and offer potential target genes for developing new therapeutic strategies for patients with retinitis pigmentosa.
Keyphrases
- rna seq
- single cell
- gene expression
- diabetic retinopathy
- nk cells
- signaling pathway
- dna methylation
- genome wide
- vascular endothelial growth factor
- oxidative stress
- ultrasound guided
- bioinformatics analysis
- genome wide identification
- optic nerve
- induced apoptosis
- epithelial mesenchymal transition
- genome wide analysis
- climate change
- endothelial cells