The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment.

Cindy C ShuSanaa ZakiVarshini RaviAntonella SchiavinatoMargaret M SmithChristopher B Little

Published in: Arthritis research & therapy (2020)

This therapeutic study in mice demonstrated a poor correlation between cartilage, bone or synovium (histo)pathology, and pain sensitization. Changes in the specific synovial inflammatory cell subpopulations may be associated with chronic OA pain sensitization, and a novel target for symptomatic treatment.

Keyphrases

postmenopausal women
bone mineral density
chronic pain
stem cells
pain management
neuropathic pain
oxidative stress
rheumatoid arthritis
type diabetes
metabolic syndrome
combination therapy
spinal cord injury
bone marrow
soft tissue