Estrogen enhances the proliferation and migration of ovarian cancer cells by activating transient receptor potential channel C3.

Shengnan LiKuo JiangJia LiXiaohua HaoWenguang ChuCeng LuoYuanyuan ZhuRougang XieBiliang Chen

Published in: Journal of ovarian research (2020)

In conclusion, TRPC3 plays a significant role in the stimulatory activity of E2 and could be a therapeutic target for the treatment of EOC. Furthermore, this study elucidates the molecular mechanism by which E2 promotes the proliferation and migration of EOC cells.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
endoplasmic reticulum stress
estrogen receptor
oxidative stress
cerebral ischemia
risk assessment
combination therapy
human health
brain injury
angiotensin ii
replacement therapy