Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis.

Yuan ZhouRong WuFei-Fei CaiWen-Jun ZhouYi-Yu LuHui ZhangQi-Long ChenMing-Yu SunShi-Bing Su

Published in: Pharmaceutical biology (2022)

This study developed a novel anti-liver formula LLAAF from XYS, and demonstrated its anti-liver fibrotic activity which may be involved in the regulation of Jak-STAT and PI3K-Akt-FoxO signalling.

Keyphrases

pi k akt
signaling pathway
liver fibrosis
cell proliferation
cell cycle arrest
human milk
single cell
transcription factor
idiopathic pulmonary fibrosis
preterm infants
low birth weight