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Fully automated measurement of plasma Aβ42/40 and p-tau181: Analytical robustness and concordance with cerebrospinal fluid profile along the Alzheimer's disease continuum in two independent cohorts.

Giovanni BellomoSherif BayoumyAlfredo MegaroAndrea TojaGiovanna NardiLorenzo GaetaniElena R BlujdeaFederico Paolini PaolettiAnna Lidia WojdaƚaDavide ChiasseriniWiesje Maria van der FlierInge M W VerberkCharlotte E TeunissenLucilla Parnetti
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
The identified cutoffs and probability-based models represent a significant step toward plasma AD molecular diagnosis.
Keyphrases
  • cerebrospinal fluid
  • machine learning
  • deep learning
  • high throughput
  • cognitive decline
  • mass spectrometry