Intuitive and deliberative styles can be considered the best-known decision-making styles, which are thought to be linked to actual workplace performance. However, there is a limited research on individual differences in these styles among individuals who provide healthcare. Therefore, adopting the self-report approach, this study examines the roles of the Big Five personality traits and socio-emotional intelligence factors in intuitive and deliberative decision-making styles among medical students and healthcare professionals. The research sample consists of 203 participants (50 medical students, 153 healthcare professionals) who completed the Big Five Inventory, the Trait Meta-Mood Scale, the Tromsø Social Intelligence Scale, and the Preference for Intuition and Deliberation Scale. The regression analyses revealed that attention to one's emotions and social information processing were positively related to intuitive decision-making style, while the clarity of one's emotions and social awareness were negatively related to intuitive decision-making style. It was further shown that conscientiousness, neuroticism, repair of one's emotions, and social information processing were positively related to deliberative decision-making style. The findings highlight the importance of personality and socio-emotional intelligence in understanding decision-making. Specifically, they point out that Big Five personality traits better explain deliberative style, while socio-emotional intelligence factors better explain intuitive style.