The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1.

Gavin E MorrisMatthew J DenniffElisavet KaramanaviSarah A AndrewsRenata B KostogrysVasiliki BountzioukaMaryam Ghaderi-NajafabadiNoor ShamkhiGeorge McConnellMichael A KaiserLaura CarletonChristine SchofieldThorsten KesslerRichard D RainbowNilesh J SamaniThomas R Webb

Published in: British journal of pharmacology (2022)

Our studies reveal a novel role for SVEP1 and the integrins α4β1 and α9β1 in reducing VSMC contractility. This could provide an explanation for the genetic associations with blood pressure risk at the SVEP1 and ITGA9 loci.

Keyphrases

genome wide
blood pressure
dna methylation
copy number
hypertensive patients
case control
single cell
genome wide association study
type diabetes
genome wide association
blood glucose
weight loss