Loss of spontaneous vasomotion precedes impaired cerebrovascular reactivity and microbleeds in a mouse model of cerebral amyloid angiopathy.
Mariel G KozbergLeon P MuntingLee H MarescoCorinne A AugerMaarten L van den BergBaudouin Denis de SennevilleLydiane HirschlerJan M WarnkingEmmanuel Luc BarbierChristian T FarrarSteven M GreenbergBrian J BacskaiSusanne J van VeluwPublished in: bioRxiv : the preprint server for biology (2024)
Our findings suggest that a decline in spontaneous vasomotion is an early, potentially pre-symptomatic, manifestation of CAA and vascular dysfunction, and a possible future treatment target.