Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke.
Ying GaoWeiqi ChenYuesong PanJing JingChunjuan WangS Claiborne JohnstonPierre AmarencoPhilip M BathLingling JiangYingying YangTingting WangShangrong HanXia MengJinxi LinXingquan ZhaoLiping LiuJinguo ZhaoYing LiYingzhuo ZangShuo ZhangHongqin YangJianbo YangYuanwei WangDali LiYanxia WangDongqi LiuGuangming KangYong-Jun WangYilong Wangnull nullPublished in: The New England journal of medicine (2024)
Among patients with mild ischemic stroke or high-risk TIA of presumed atherosclerotic cause, combined clopidogrel-aspirin therapy initiated within 72 hours after stroke onset led to a lower risk of new stroke at 90 days than aspirin therapy alone but was associated with a low but higher risk of moderate-to-severe bleeding. (Funded by the National Natural Science Foundation of China and others; INSPIRES ClinicalTrials.gov number, NCT03635749.).