Rhizomucor pusillus Infection in a Patient with Acute Myeloid Leukaemia After Haematopoietic Stem Cell Transplantation: Clinical Impact of Metagenomics Next-Generation Sequencing.
Lilin LiuHuiqin WuJianghong LiangWenhao WuYe PengHua ZhouXi LiPublished in: Infection and drug resistance (2022)
Long-term chemotherapy and immunosuppressants in acute myeloid leukaemia (AML) patients can result in a high risk of opportunistic infections. Rhizomucor pusillus is an opportunistic pathogen that exists in nature, but infection caused by R. pusillus is rare in the clinic. Notably, the sensitivity and detection time of conventional diagnostic tools for this fungus usually falls short of the needs of clinical diagnosis, resulting in treatment failure. Currently, metagenomics next-generation sequencing (mNGS) has played an important role in the detection of pathogens. Here, we report a case of R. pusillus pneumonia in a haematopoietic stem cell transplantation (HSCT) patient, detected by the mNGS method.
Keyphrases
- stem cell transplantation
- high dose
- liver failure
- respiratory failure
- acute myeloid leukemia
- end stage renal disease
- case report
- dendritic cells
- bone marrow
- ejection fraction
- newly diagnosed
- drug induced
- loop mediated isothermal amplification
- primary care
- aortic dissection
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- label free
- low dose
- extracorporeal membrane oxygenation
- real time pcr
- squamous cell carcinoma
- locally advanced
- rectal cancer
- mechanical ventilation
- hematopoietic stem cell