Evaluation of UGT1A1 and CYP3A Genotyping and Single-Point Irinotecan and Metabolite Concentrations as Predictors of the Occurrence of Adverse Events in Cancer Treatment.

Jeziel BassoGilberto SchwartsmannMariana Rodrigues IbaldiVitoria Daniela SchaeferCarla Casagrande PaveiRoberta Zilles HahnMarina Venzon AntunesRafael Linden

Published in: Journal of gastrointestinal cancer (2022)

Our data confirmed the relevance of the pre-emptive genotypic information of UGT1A1. The [SN-38]/IRI ratio, measured 15 min after the end of the IRI infusion, was a strong predictor of severe toxicity and could be applied to minimize the burden of patients after IRI administration.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
low dose
peritoneal dialysis
oxidative stress
healthcare
high throughput
genome wide
gene expression
electronic health record
patient reported outcomes
health information
deep learning
machine learning
social media
genetic diversity