BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia.

Yafeng ZhouJianbiao ZhouXiao LuTuan-Zea TanWee-Joo Chng

Published in: BMC cancer (2018)

These findings provide novel insight on how BET inhibitor can induce apoptosis in AML, and further support the development of BET inhibitors as a promising therapeutic strategy against AML.

Keyphrases

acute myeloid leukemia
oxidative stress
signaling pathway
allogeneic hematopoietic stem cell transplantation
endoplasmic reticulum stress
cell cycle arrest
cell death