Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer's disease.

Denise VisserSander C J VerfaillieEmma E WoltersEmma M CoomansTessa TimmersHayel TuncelRonald BoellaardSandeep S V GollaAlbert D WindhorstPhilip ScheltensWiesje M van der FlierBart N M van BerckelRik Ossenkoppele

Published in: European journal of nuclear medicine and molecular imaging (2022)

Compared to LOAD, the degree of lateral temporal and occipitoparietal tau pathology and relative cerebral blood-flow is more strongly associated with cognition in EOAD.

Keyphrases

late onset
early onset
blood flow
cerebral blood flow
cerebrospinal fluid
cognitive decline
mild cognitive impairment
minimally invasive