Clonally expanded PD-1hi CXCR5- CD4+ peripheral T helper cells promote differentiation of CD21lo/- CD11c+ double negative B cells in the joints of ANA+ JIA patients.

Jonas FischerJohannes DirksJulia KlaussnerGabriele HaaseAnnette Holl-WiedenChristine HofmannStephan HackenbergHermann GirschickHenner Morbach

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Clonally expanded CD4+ TPH cells accumulate in the joints of ANA+ JIA patients and particularly promote CD21lo/- CD11c+ BDN cell differentiation The expansion of TPH and BDN cells might reflect the autoimmune response present in the joints of ANA+ JIA patients.

Keyphrases

end stage renal disease
induced apoptosis
newly diagnosed
chronic kidney disease
peritoneal dialysis
multiple sclerosis
cell cycle arrest
cell death
endoplasmic reticulum stress
signaling pathway
immune response
juvenile idiopathic arthritis
systemic lupus erythematosus