Clonally expanded PD-1hi CXCR5- CD4+ peripheral T helper cells promote differentiation of CD21lo/- CD11c+ double negative B cells in the joints of ANA+ JIA patients.
Jonas FischerJohannes DirksJulia KlaussnerGabriele HaaseAnnette Holl-WiedenChristine HofmannStephan HackenbergHermann GirschickHenner MorbachPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Clonally expanded CD4+ TPH cells accumulate in the joints of ANA+ JIA patients and particularly promote CD21lo/- CD11c+ BDN cell differentiation The expansion of TPH and BDN cells might reflect the autoimmune response present in the joints of ANA+ JIA patients.