Verbena Attenuates Adriamycin-Induced Renal Tubular Injury via Inhibition of ROS-ERK1/2-NLRP3 Signal Pathway.
Yicen ZhouQijing WuZhenfang DuMin HuangKun GaoXiaowei MaHui ZhangSheng QiangWei SunPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
Chronic kidney disease (CKD) has become a global public health problem. Tubular epithelial cell injury plays a vital role in the progression and prognosis of CKD. Therapies to protect tubular cells is the key to delaying CKD progression. Our study found that verbena, a natural traditional Chinese herb, has a potential reno-protective role in kidney diseases. However, the detailed mechanism remains unknown. In the current study, we employed adriamycin (ADR)-induced renal tubular cell injury to mimic the conditions of tubular injury in vitro. Results showed that total aqueous exact of verbena (TAEV) ameliorated ADR-induced cell disruption, loss of cellular viability, and apoptosis via inhibition of ROS-ERK1/2-mediated activation of NLRP3 signal pathway, suggesting that TAEV serves as a promising renoprotective agent in delaying the progression of CKD, while ROS-ERK1/2-mediated NLRP3 signal pathway might be a novel target in treating kidney diseases.
Keyphrases
- high glucose
- chronic kidney disease
- endothelial cells
- end stage renal disease
- public health
- cell death
- signaling pathway
- diabetic rats
- cell cycle arrest
- dna damage
- cell proliferation
- oxidative stress
- single cell
- reactive oxygen species
- induced apoptosis
- cell therapy
- drug induced
- endoplasmic reticulum stress
- climate change
- diabetic nephropathy
- bone marrow
- molecular dynamics