Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system.
Machika HamaguchiRieko MuramatsuHarutoshi FujimuraHideki MochizukiHirotoshi KataokaToshihide YamashitaPublished in: eLife (2019)
Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present in higher levels in the systemic environment, promotes oligodendrocyte maturation. Oligodendrocyte maturation was enhanced by adult mouse serum treatment via TGF-β type I receptor. Decrease in circulating TGF-β1 level prevented remyelination in the spinal cord after toxin-induced demyelination. TGF-β1 administration promoted remyelination and restored neurological function in a multiple sclerosis animal model. Furthermore, TGF-β1 treatment stimulated human oligodendrocyte maturation. These data provide the therapeutic possibility of TGF-β for demyelinating diseases.
Keyphrases
- transforming growth factor
- epithelial mesenchymal transition
- multiple sclerosis
- spinal cord
- stem cells
- signaling pathway
- spinal cord injury
- deep learning
- brain injury
- machine learning
- young adults
- oxidative stress
- diabetic rats
- subarachnoid hemorrhage
- replacement therapy
- induced pluripotent stem cells
- wound healing
- artificial intelligence
- stress induced