Surveillance Imaging vs Symptomatic Recurrence Detection and Survival in Stage II-III Breast Cancer (AFT-01).
Jessica R SchumacherHeather B NeumanMenggang YuDavid J VannessYajuan SiElizabeth S BurnsideKathryn J RuddyAnn H PartridgeDeborah SchragStephen B EdgeYing ZhangElizabeth A JacobsJeffrey HavlenaAmanda B FrancescattiDavid P WinchesterDaniel P McKellarPatricia A SpearsBenjamin D KozowerGeorge J ChangCaprice C Greenbergnull nullPublished in: Journal of the National Cancer Institute (2022)
Recurrence detection by asymptomatic imaging compared with signs and/or symptoms was associated with lower risk of death for triple-negative and HER2-positive, but not ER- or PR-positive, HER2-negative cancers. A randomized trial is warranted to evaluate imaging surveillance for metastases results in these subgroups.