Neurological abnormalities in individuals with Marfan syndrome: results from a genetically confirmed Italian cohort.

Matteo BeniniMatteo FoschiValentina BaroneGianfranco VornettiLuca SpinardiElisabetta MariucciAndrea DontiPietro CortelliMaria Guarino

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024)

Our study confirms that neurological abnormalities are frequent in individuals with MFS. While migraine appears to be associated with brain vessels tortuosity, brain parenchymal abnormalities are typical of individuals with a prior history of aortic surgery. Larger prospective studies are needed to understand the relationship between parenchymal abnormalities and long-term cognitive outcomes.

Keyphrases

cerebral ischemia
resting state
white matter
minimally invasive
functional connectivity
coronary artery bypass
aortic valve
left ventricular
case report
metabolic syndrome
aortic dissection
adipose tissue
pulmonary artery
pulmonary hypertension
blood brain barrier
skeletal muscle
weight loss