Metabolome and transcriptome analysis on muscle of sporadic inclusion body myositis.

Ayuka MurakamiSeiya NodaTomoyuki KazutaSatoko HiranoSeigo KimuraHirotaka NakanishiKoji MatsuoKoyo TsujikawaMadoka IidaHaruki KoikeKazuma SakamotoYuichiro HaraSatoshi KuruKenji KadomatsuTeppei ShimamuraTomoo OgiMasahisa Katsuno

Published in: Annals of clinical and translational neurology (2022)

We identified alterations of several metabolic pathways in muscle samples of sIBM patients. These results suggest that mast cells, chondroitin sulfate biosynthesis, carnitine, and creatine play roles in sIBM pathophysiology.

Keyphrases

end stage renal disease
skeletal muscle
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
late onset
rheumatoid arthritis
idiopathic pulmonary fibrosis