Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy.
Ian C WenkerFrida A TeranEric R WengertPravin K WagleyPayal S PanchalElizabeth A BlizzardPriyanka SarafJacy L WagnonHoward P GoodkinMiriam H MeislerGeorge B RichersonManoj K PatelPublished in: Annals of neurology (2021)
We conclude that apnea coincident with the tonic phase of a seizure, and subsequent failure to resume breathing, are the determining events that cause seizure-induced death in Scn8a mutant mice. ANN NEUROL 2021;89:1023-1035.