N-Butyl-4-hydroxy-1,8-naphthalimide: A new matrix for small molecule analysis by matrix-assisted laser desorption/ionization mass spectrometry.

Xina ChengXueting YeDan LiuNan ZhaoHuiyuan GaoPing WangGuangbo GeXiaozhe Zhang

Published in: Rapid communications in mass spectrometry : RCM (2018)

The new matrix BHN has exhibited suitability for the analysis of small molecules. Compared with the conventional matrices, CHCA and DHB, BHN provides a clean background in the low-mass region. In combination with DHB, the ability of BHN to form highly homogenous crystalline particles shows the clear beneficial effects of BHN for the reproducibility of MS detection.

Keyphrases

mass spectrometry
small molecule
multiple sclerosis
high performance liquid chromatography
capillary electrophoresis
fluorescent probe
loop mediated isothermal amplification
simultaneous determination