Rosette-forming glioneuronal tumours are midline, FGFR1-mutated tumours.
Romain AppayFranck BiellePhilipp SieversDoriane BaretsFrédéric FinaJean BoutonnatClovis AdamGuillaume GauchotteCatherine GodfraindBenoît LhermitteClaude-Alain MaurageDavid MeyronetKarima MokhtariAudrey RousseauArnault Tauziède-EspariatMarie-Claire TortelEmmanuelle Uro-CosteFanny Burel VandenbosGuillaume ChotardFlorian PescePascale VarletCarole ColinDominique Figarella BrangerPublished in: Neuropathology and applied neurobiology (2022)
We suggest adding FGFR1 mutation and intracranial midline location as essential diagnostic criteria. When DNA methylation profiling is not available, a RGNT diagnosis remains certain in cases demonstrating characteristic pathological features and FGFR1 mutation associated with either PIK3CA or PIK3R1 mutation.