Implementation of First-trimester Screening and Prevention of Preeclampsia: a Stepped Wedge Cluster-randomized Trial in Asia.
Long Nguyen-HoangLinh Thuy DinhAngela S T TaiNguyen Duy AnhRitsuko Kimata PoohArihiro ShiozakiMingming ZhengYali HuBin LiRaden Aditya KusumaPiengbulan YapanArundhati GosaviMayumi KanekoSuchaya LuewanTung-Yao ChangNoppadol ChaiyasitTongta NanthakomonHuishu LiuSteven W ShawWing Cheong LeungZaleha Abdullah MahdyAngela AguilarHillary H Y LeungNikki M W LeeSo Ling LauYi Man Isabella WahXiaohong LuDaljit Singh SahotaMarc Ka Chun ChongLiona Chiu Yee PoonPublished in: Circulation (2024)
The implementation of the screen-and-prevent strategy for preterm PE is not associated with a significant reduction in the incidence of preterm PE. However, low-dose aspirin effectively reduces the incidence of preterm PE by 41% among high-risk women. The screen-and-prevent strategy for preterm PE is highly accepted by a diverse group of women from various ethnic backgrounds beyond the original population where the strategy was developed. These findings underpin the importance of the widespread implementation of the screen-and-prevent strategy for preterm PE on a global scale.