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CGRP outflow into jugular blood and cerebrospinal fluid and permeance for CGRP of rat dura mater.

Miriam RischBirgit VoglerMária DuxKarl Messlinger
Published in: The journal of headache and pain (2021)
We conclude that only a small fraction of CGRP applied onto the dura mater reaches the jugular blood and, in a delayed manner, also the CSF. The dura mater may constitute a barrier for CGRP and limits diffusion into the CSF of the subarachnoidal space, where the CGRP concentration is too low to cause vasodilatation.
Keyphrases
  • cerebrospinal fluid
  • ultrasound guided
  • oxidative stress