CGRP outflow into jugular blood and cerebrospinal fluid and permeance for CGRP of rat dura mater.
Miriam RischBirgit VoglerMária DuxKarl MesslingerPublished in: The journal of headache and pain (2021)
We conclude that only a small fraction of CGRP applied onto the dura mater reaches the jugular blood and, in a delayed manner, also the CSF. The dura mater may constitute a barrier for CGRP and limits diffusion into the CSF of the subarachnoidal space, where the CGRP concentration is too low to cause vasodilatation.