Epigenetic signature of exposure to maternal Trypanosoma cruzi infection in cord blood cells from uninfected newborns.
Hans DesalePierre M BuekensJackeline AlgerMaria Luisa CafferataEmily Wheeler HarvilleClaudia P HerreraCarine TruyensEric DumonteilPublished in: Epigenomics (2022)
Aims: To assess the epigenetic effects of in utero exposure to maternal Trypanosoma cruzi infection. Methods: We performed an epigenome-wide association study to compare the DNA methylation patterns of umbilical cord blood cells from uninfected babies from chagasic and uninfected mothers. DNA methylation was measured using Infinium EPIC arrays. Results: We identified a differential DNA methylation signature of fetal exposure to maternal T. cruzi infection, in the absence of parasite transmission, with 12 differentially methylated sites in B cells and CD4 + T cells, including eight protein-coding genes. Conclusion: These genes participate in hematopoietic cell differentiation and the immune response and may be involved in immune disorders. They also have been associated with several developmental disorders and syndromes.
Keyphrases
- dna methylation
- trypanosoma cruzi
- genome wide
- cord blood
- gene expression
- hiv infected
- umbilical cord
- birth weight
- immune response
- mesenchymal stem cells
- copy number
- gestational age
- pregnancy outcomes
- pregnant women
- genome wide identification
- toll like receptor
- small molecule
- physical activity
- toxoplasma gondii
- binding protein