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Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men.

Laura G M JanssenAndrea D Van DamMark J W HanssenSander KooijmanKimberly J NahonHanneke ReindersIngrid M JazetWouter D Van Marken LichtenbeltPatrick C N RensenNatasha M Appelman-DijkstraMariëtte R Boon
Published in: Diabetes & metabolism journal (2019)
South Asian men with overweight or obesity and prediabetes have higher plasma sclerostin and lower Wnt signaling gene expression in WAT compared with white Caucasians. We interpret that reduced Wnt signaling could contribute to impaired insulin signaling in South Asians.
Keyphrases
  • gene expression
  • adipose tissue
  • type diabetes
  • dna methylation
  • insulin resistance
  • middle aged
  • weight loss
  • weight gain
  • metabolic syndrome
  • african american
  • glycemic control