Shugan granule contributes to the improvement of depression-like behaviors in chronic restraint stress-stimulated rats by altering gut microbiota.

Junnan LiYannan LiWenzhe DuanZhonghui ZhaoLixuan YangWei WeiJingchun LiYang LiYao YuBaoan DaiRong-Juan Guo

Published in: CNS neuroscience & therapeutics (2022)

SGKL targets the PI3K/Akt/mTOR pathway by altering gut microbiota and metabolites, which ameliorates altered behavior and inflammation in the hippocampus.

Keyphrases

oxidative stress
stress induced
ms ms
depressive symptoms
sleep quality
mouse model
cognitive impairment
prefrontal cortex
cerebral ischemia
drug induced
subarachnoid hemorrhage
brain injury
blood brain barrier