Single-cell profiling reveals immune aberrations in progressive idiopathic pulmonary fibrosis.

Avraham UntermanAmy Y ZhaoNir NeumarkJonas C SchuppFarida AhangariCarlos CosmePrapti SharmaJasper FlintYan SteinChangwan RyuGenta IshikawaTomokazu S SumidaJose L GomezJose Herazo-MayaCharles S Dela CruzErica L HerzogNaftali Kaminski

Published in: medRxiv : the preprint server for health sciences (2023)

The single-cell atlas of the peripheral immune system in IPF, reveals an outcome-predictive increase in classical monocytes and Tregs, as well as evidence for a lung-blood immune recruitment axis involving CCL7 (for classical monocytes) and CCL18/CCL22 (for Tregs).

Keyphrases

single cell
idiopathic pulmonary fibrosis
rna seq
liver fibrosis
liver injury
interstitial lung disease
high throughput
dendritic cells
multiple sclerosis
peripheral blood
copy number
gene expression
immune response
chemotherapy induced