XPC as breast cancer susceptibility gene: evidence from genetic profiling, statistical inferences and protein structural analysis.

Saima Shakil MalikAyisha ZiaSajid RashidSumaira MubarikNosheen MasoodMubashar HussainAzra YasminRazia Bano

Published in: Breast cancer (Tokyo, Japan) (2020)

In conclusion, both XPC polymorphisms confer significant association with increased BC risk. rs2228001 substitution may change the structural and functional preferences of XPC C-terminus, while rs2733532 may have regulatory role thereby leading to potential BC risk.

Keyphrases

genome wide
copy number
transcription factor
single cell
gene expression
risk assessment
young adults
binding protein
protein protein
amino acid
decision making
breast cancer risk
childhood cancer