Bacteria mimics bearing carbohydrates, oligodeoxynucleotides and designed shapes.

We utilize a facile and gentle strategy to fabricate bacteria mimics ("bacillus" and "coccus") endowed with carbohydrates, oligodeoxynucleotides and designed shapes via dopamine-polymer based nanoparticle fabrication and DNA-based multivalent interactions. These bacteria mimics with TLR- and CLR-targeted capabilities are demonstrated to exhibit enhanced immune stimulating efficiency.