Glycolytic PFKFB3 and Glycogenic UGP2 Axis Regulates Perfusion Recovery in Experimental Hind Limb Ischemia.
Olukemi JaiyesimiSivaraman KuppuswamyGuangwei ZhangSonia BatanWenbo ZhiVijay C GantaPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our data present that inhibition of maladaptive PFKFB3-driven glycolysis in HSS-ECs is necessary to promote the UGP2-uridine diphosphate-glucose axis that enhances ischemic angiogenesis and perfusion recovery in experimental PAD.
Keyphrases
- contrast enhanced
- endothelial cells
- electronic health record
- vascular endothelial growth factor
- big data
- blood glucose
- type diabetes
- ischemia reperfusion injury
- magnetic resonance imaging
- machine learning
- computed tomography
- oxidative stress
- blood pressure
- cerebral ischemia
- brain injury
- data analysis
- adipose tissue
- weight loss
- insulin resistance
- deep learning