Introducing fluorescence guided surgery into orthopedic oncology: A systematic review of candidate protein targets for Ewing sarcoma.
Sarah E BosmaPieter Baa van DrielPancras Cw HogendoornPd Sander DijkstraCornelis Fm SierPublished in: Journal of surgical oncology (2018)
Ewing sarcoma (ES), an aggressive bone and soft-tissue tumor, is treated with chemotherapy, radiotherapy, and surgery. Intra-operative distinction between healthy and tumorous tissue is of paramount importance but challenging, especially after chemotherapy and at complex anatomical locations. Near infrared (NIR) fluorescence-guided surgery (FGS) is able to facilitate the determination of tumor boundaries intra-operatively, improving complete resection and therefore survival. This review evaluates potential ES-specific proteins from the literature as targets for NIR FGS.
Keyphrases
- minimally invasive
- coronary artery bypass
- soft tissue
- locally advanced
- surgical site infection
- photodynamic therapy
- systematic review
- palliative care
- fluorescence imaging
- squamous cell carcinoma
- drug release
- bone mineral density
- coronary artery disease
- radiation induced
- percutaneous coronary intervention
- risk assessment
- rectal cancer
- high resolution
- postmenopausal women
- quantum dots
- chemotherapy induced