In-silico analysis reveals druggable single nucleotide polymorphisms in angiotensin 1 converting enzyme involved in the onset of blood pressure.
Brenda UdosenOpeyemi SoremekunChinwe EkennaOlaposi Idowu OmotuyiTinashe ChikoworeOyekanmi NashiruSegun FatumoPublished in: BMC research notes (2021)
Our study revealed that five nsSNPs of the ACE1 gene were found to be potentially deleterious and damaging and they include rs2229839, rs14507892, rs12709442, and rs4977 at point mutations P351R, R953Q, I1018T, F1051V, and T1187M. The protein stability predictive tools revealed that all the nsSNPs decreased stability of the protein and the Consurf server which estimates the evolutionary conservation profile of a protein showed that three mutants were in the highly conserved region. In conclusion, this study predicted potential druggable deleterious mutants that can be further explored to understand the pathological basis of cardiovascular disease.
Keyphrases
- angiotensin converting enzyme
- cardiovascular disease
- blood pressure
- protein protein
- angiotensin ii
- gene expression
- type diabetes
- genome wide
- amino acid
- small molecule
- risk assessment
- skeletal muscle
- molecular docking
- coronary artery disease
- dna methylation
- weight loss
- cardiovascular events
- copy number
- blood glucose
- glycemic control