Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis.

Mathilde SollierMarine HalbronJean DonadieuAhmed IdbaïhFleur Cohen AubartCorinne VigourouxMartine AuclairOlivier BourronMarie BastinGéraldine BéraPhilippe TouraineJacques YoungHéléna MosbahAgnès HartemannFabrizio AndreelliChloé Amouyal

Published in: Case reports in endocrinology (2019)

We report the first description of a hypothalamopituitary histiocytosis associated with serum anti-insulin receptor antibodies, extreme insulin resistance, and diabetes. Parallel evolution of glucose levels and serum anti-insulin receptor antibodies seemed to be the consequence of immune suppressive properties of cladribine.

Keyphrases

glycemic control
type diabetes
insulin resistance
blood glucose
induced apoptosis
high fat diet
polycystic ovary syndrome
metabolic syndrome
climate change
cardiovascular disease
skeletal muscle
high fat diet induced
cell cycle arrest
weight loss
endoplasmic reticulum stress
signaling pathway
blood pressure