Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction, and renal dysmorphology in a primate model.
Erin BolteTyler DeanBrandon GarciaMaxim D SeferovicKristin SauterGwendolynn HummelMatthew BucherFeng LiJohn HicksXuan QinMelissa A SuterEnrico R BarrozoMichael JochumCynthia ShopeJacob E FriedmanMaureen GannonStephanie R WesolowskiCarrie E McCurdyPaul KievitKjersti M AagaardPublished in: American journal of obstetrics and gynecology (2024)
Our study demonstrates fetal bioaccumulation of metformin with associated fetal growth restriction and renal dysmorphology after maternal initiation of the drug within 30 days of conception in primates. Given these results and the prevalence of metformin use during pregnancy, additional investigation of any potential immediate and enduring effects of prenatal metformin use is warranted.