Storage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice.

Cheryl L MaierRyan P JajoskySeema R PatelHans P VerkerkeMegan D FullerJerry William AllenPatricia E ZerraRoss M FasanoSatheesh ChonatCassandra D JosephsonDavid R GibbStephanie C EisenbarthC John LuckeyKrystalyn E HudsonJeanne E HendricksonConnie M ArthurSean R Stowell

Published in: Transfusion (2023)

These data demonstrate a dichotomous impact of storage on immunization to distinct RBC antigens, offering a possible explanation for inconsistent clinical experience and the need for additional studies on the relationship between RBC storage and alloimmunization.

Keyphrases

sickle cell disease
dendritic cells
single cell
red blood cell
cell therapy
stem cells
big data
immune response
case control
insulin resistance
wild type