Login / Signup

Management of Allogeneic Stem Cell Transplantation for High-Risk AML following SARS-CoV-2 Associated Pancytopenia with Marked Bone Marrow Biopsy Alterations.

Maria KaparouZbigniew RudzkiHannah GilesVidhya MurthySwathy SrinathRebecca LloydMaria Zahid AhmedBeena SalhanSaleena ChauhanBhuvan KishoreRichard LovellClaire HorganShankara PaneeshaEvgenia XenouAnand LokareJoanne EwingHansini DassanayakeEmmanouil NikolousisAlexandros Kanellopoulos
Published in: Case reports in hematology (2021)
The present study describes a patient aged 70 with very high-risk AML who successfully received a nonmyeloablative matched unrelated donor allograft shortly following SARS-CoV-2 infection, which manifested with mild cough, interstitial abnormalities on chest CT, and pancytopenia with profound bone marrow biopsy histological alterations. In parallel, our study provides bone marrow biopsy data in a series of contemporary patients with serious haematological diseases who had a bone marrow biopsy performed within two weeks of PCR confirmation of SARS-CoV-2 infection. This study is notable because there are no published data describing the bone marrow biopsy changes observed in patients with haematological malignancies and SARS-CoV-2 infection. Finally, it is suggested that nonmyeloablative hematopoietic stem cell transplantation for very high-risk haematological malignancies can be successfully performed following recovery from SARS-CoV-2 infection.
Keyphrases