Hepatitis B Virus-Telomerase Reverse Transcriptase Promoter Integration Harnesses Host ELF4, Resulting in Telomerase Reverse Transcriptase Gene Transcription in Hepatocellular Carcinoma.

Karen Man-Fong SzeDaniel Wai-Hung HoYung-Tuen ChiuYu-Man TsuiLo-Kong ChanJoyce Man-Fong LeeKenneth Siu-Ho ChokAlbert Chi-Yan ChanChung-Ngai TangVictor Wai-Lun TangIrene Lai-Oi LoDerek Tsz-Wai YauTan-To CheungIrene Oi Lin Ng

Published in: Hepatology (Baltimore, Md.) (2020)

Our results reveal a cis-activating mechanism harnessing host ELF4 and HBV integrated at the TERT promoter and uncover how TERT HBV-integrated HCCs may achieve TERT activation in hepatocarcinogenesis.

Keyphrases

hepatitis b virus
transcription factor
dna methylation
genome wide
liver failure
gene expression
signaling pathway
copy number
genome wide identification
big data
machine learning
deep learning
genome wide analysis